Science

CNS disorders like traumatic brain injury (TBI), PTSD, depression, anxiety and substance use disorders (SUDs) encompass a wide range of symptoms, including cognitive impairment, behavioral changes, problems with movement and emotional disturbances. TBI and its associated conditions affect 2.8 million Americans,¹ nearly ⅓ of the U.S. population. Combat-exposed Veterans experience TBIs at over 10 times the civilian rate ^{2, 3} and suffer from elevated suicide rates 57% higher than the general population.⁴

• ¹https://biausa.org/public-affairs/public-awareness/brain-injury-awareness
• ²https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788981
• ³https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788981
• ⁴https://www.mentalhealth.va.gov/docs/data-sheets/2022/2022-National-Veteran-Suicide-Prevention-Annual-Report-FINAL-508.pdf

Ibogaine is a naturally occurring alkaloid with broad neuromodulatory effects that may facilitate improvement in symptoms associated with challenging neuropsychiatric disorders. When administered, ibogaine is believed to affect multiple neurotransmitters and increase expression of multiple trophic factors thought to enhance neuroplasticity. Ibogaine has been used for centuries in healing and initiation rituals.